Endocrine Abstracts

Introduction: Flash glucose monitoring (FGM) enables people with diabetes to regularly track their glucose levels without performing capillary finger-stick measurements (SMBG). Clinical studies have shown improvement in glycemic control, reduction of hypoglycemia, improvement in comfort and quality of life in people with type 1 diabetes (T1D) using this technology. In contrast to continuous glucose monitoring, FGM requires the performance of a scan to obtain the current glucos...

Objective: Polycystic ovary syndrome (PCOS) affects 5–20% of women of reproductive age worldwide and is associated with disorders of glucose metabolism. Hormone and metabolic signalling may be influenced by phytoestrogens, such as isoflavones. Their endocrine effects may modify symptom penetrance in PCOS.We investigated, whether women with PCOS and healthy controls differ in their capacity to metabolize dietary isoflavones and whether this capacity...

Background: PD-L1 represents a novel class of drugs for treatment of a broad spectrum of malignancies including onco-hematologic diseases. This treatment is associated with several immuno-related adverse events (irAEs). Thyroid diseases and diabetes are among the most common PD-L1 endocrine-irAEs reported in solid cancers.Aims: To describe the frequency, the onset and the characteristics of PD-L1 endocrine-irAEs in patients with hematologic malignancies....

Background: In the last years, Pembrolizumab has been used to treat solid and lymphatic neoplasms, showing improved patients’ survival. Due to its mechanism of action, Pembrolizumab may be responsible of several immune-related adverse events (irAEs). The most frequent endocrine-irAEs reported are thyroid diseases.Aims: The aim of this study was to evaluate differences in thyroid disease incidence and presentation between patients treated for lung c...

The Society for Endocrinology Nurse Committee provides national, international and local guidance, support and networking for nurses working in Endocrinology. Following review and revalidation of the endocrine nurse certificate, the Nurse Committee looked to explicate adult endocrine nurse competencies. The need for core competencies to standardise role expectations was a concern voiced from nurses and committee members. Up to the introduction of paediatric endocrine nurse com...

Amyotrophic lateral sclerosis (ALS), the most common motor neurone disorder in human adults, presents is characterized by selective and progressive degeneration of upper and lower motor neurones in central nervous system. GH secretion, evaluated by GHRH+arginine test, has been recently reported to be impaired in about 70% of untreated ALS patients. The currently available drug for ALS treatment is riluzole, a compound acting through inhibition of glutamate relase, post-synapti...

Objectives: There is still an unmet need for an effective systemic therapy for advanced medullary thyroid carcinoma (MTC). Targeting the cholecystokinine-2 (CCK-2) receptor with radiolabelled gastrin analogues is a potential approach for radionuclide therapy, as MTC expresses CCK-2 receptors at a high incidence and density. Unfortunately, kidney and bone marrow toxicity precluded therapeutic applications of CCK-2 receptor specific compounds until now. The aim of this prospecti...

Background: Patients with primary adrenal insufficiency (PAI) carry an increased risk of infections which can precipitate adrenal crises. They are thought to be more likely to contract COVID-19 and develop severe disease; however, little is known about the true impact of COVID-19 on these patients.Objectives: To assess the response of a large single-centre cohort of PAI patients to COVID-19, focusing on morbidity and health promotion attitudes.<p cla...

Background: An adrenal incidentaloma (AI) is an adrenal lesion found on imaging performed for an indication other than adrenal disease. The current European Society of Endocrinology guidelines recommend that all AIs are discussed in a dedicated adrenal multidisciplinary meeting.Method: We evaluated the outcomes of AI cases referred to the Adrenal Radiology Meeting (ARM) at Heartlands Hospital between January 2021 and Dec...

Objective: Time-restricted eating (TRE) represents a novel intervention that may improve insulinaemia and reduce weight, but is untested in polycystic ovarian syndrome (PCOS). In a randomised interventional study (NCT05126199), we investigated the feasibility of TRE in PCOS. Secondary objectives included effects on insulin and metabolic indices.Methods: Participants were randomised to 12-week TRE (18h fast/6h eating wind...